Modification Refers to a change adopted by the Secretary, through regulation, to a standard or an implementation specification. [45 CFR 160.103] Legislation Files Containing This Term: legislation/45CFR-160.103.html legislation/45CFR-160.104.html legislation/45CFR-162.1002.html legislation/45CFR-162.103.html legislation/45CFR-162.910.html legislation/45CFR-162.940.html