Trading Partner Agreement (TPA) An agreement related to the exchange of information in electronic transactions, whether the agreement is distinct or part of a larger agreement, between each party to the agreement. [45 CFR 160.103] For example, a trading partner agreement may specify, among other things, the duties and responsibilities of each party to the agreement in conducting a standard transaction. Legislation Files Containing This Term: legislation/45CFR-160.103.html legislation/45CFR-162.915.html